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Decreased response inhibition in middle-aged male patients with type 2 diabetes

Kaya T Ishizawa1, Hiroaki Kumano2*, Atsushi Sato3, Hiroshi Sakura1 and Yasuhiko Iwamoto1

Author Affiliations

1 the Diabetes Center, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo 162-8666, Japan

2 Faculty of Human Sciences, Waseda University, 2-579-15 Mikashima, Tokorozawa-shi, Saitama 359-1192, Japan

3 Faculty of Human Development, University of Toyama, 3190 Gofuku, Toyama-shi, Toyama 930-8555, Japan

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BioPsychoSocial Medicine 2010, 4:1  doi:10.1186/1751-0759-4-1

Published: 11 February 2010



This study was performed to examine whether patients with type 2 diabetes have cognitive deficits associated with the prefrontal cortex (PFC).


Twenty-seven middle-aged patients with newly diagnosed type 2 diabetes and 27 healthy controls underwent physical measurements and neuropsychological tasks. Response inhibition, reward prediction, and executive function were assessed by the Go/NoGo task, the reversal and extinction tasks, and the Wisconsin Card Sorting Test (WCST). To examine the interactions of being overweight with diabetes on cognitive performance, performance data were analysed by two-way ANCOVA with diabetes and overweight as factors and age as a covariate.


Patients with type 2 diabetes showed significantly decreased response inhibition in the Go/NoGo task (discriminability index: P = 0.001). There was an interaction of being overweight with diabetes on reaction time in the Go trials of the Go/NoGo task (P = 0.009). Being overweight was related to retained responses to the presentiment of reward in the extinction task (P = 0.029). The four groups showed normal cognitive performance in the WCST.


Our results showed that middle-aged, newly diagnosed and medication-free patients with type 2 diabetes have a particular neuropsychological deficit in inhibitory control of impulsive response, which is an independent effect of diabetes apart from being overweight.