Open Access Short report

Comparison of temporal changes in psychological distress after hematopoietic stem cell transplantation among the underlying diseases of Japanese adult patients

Wataru Fukuo1, Kazuhiro Yoshiuchi1*, Yoshiyuki Takimoto1, Noriyuki Sakamoto1, Hiroe Kikuchi1, Maki Hachizuka1, Shuji Inada1, Yasuhito Nannya2, Keiki Kumano3, Tsuyoshi Takahashi2, Mineo Kurokawa23 and Akira Akabayashi1

Author Affiliations

1 Department of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan

2 Department of Hematology/Oncology, the University of Tokyo, Tokyo, Japan

3 Department of Cell Therapy and Transplantation Medicine, the University of Tokyo, Tokyo, Japan

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BioPsychoSocial Medicine 2008, 2:24  doi:10.1186/1751-0759-2-24

Published: 21 November 2008



Although hematopoietic stem cell transplantation (HSCT) can potentially cure some hematological malignancies, patients who undergo HSCT experience psychological distress. However, there have been few studies on the short-term influence of HSCT on psychological distress.


The subjects were 71 patients with hematological malignancies who underwent HSCT: 33 with acute leukemia, 19 with chronic leukemia, nine with myelodysplastic syndrome, and 10 with malignant lymphoma. Psychological distress was assessed prior to HSCT and on the seventh day after HSCT using the Profile of Mood States (POMS).


With regard to Anger-Hostility, the interaction of time (pre- and post-HSCT) and group (the four groups) was significant in male patients (p = 0.04), but not in female patients. With regard to the other subscales of POMS, there was no significant main effect or interaction in male or female patients.


It may be important to provide psychological support to patients throughout the period of HSCT in consideration of differences in mood changes associated with the underlying disease and patient sex in order to provide efficient psychiatric intervention for both better psychiatric and survival outcomes.